Benchmark the card in a game with it both on and off. Then choose which one gives better results.
Intuition tells me that it's a good thing, but it doesn't hurt to experiment.
Also, +1 for the gtx 260. Get the 1gb version btw, higher bandwidth in addition to more memory.
still not a 4ghz processor :P anyway it will be able to run the gtx 460 but for optimal usage you might want to get a 500w psu in case you have any extras like a secondary hdd or 2 dvd/cd drives